Genomics Team

The main function of the Genomics Team is to uncover the underlying genetic loci contributing to Alopecia Areata disease. In 2015, the Christiano Lab conducted a genome-wide association study(GWAS) that uncovered common variants in 14 AA-susceptibility loci. Since then, follow-up linkage and copy number variant (CNV) studies have been used to further investigate the genetic burden of Alopecia Areata. The Genomics team is currently working to integrate exome sequencing, custom capture genome sequencing, microarray expression data, and T-cell sequencing data to identify candidate variants and their functional annotations.